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Included Studies

Asarnow JR, Jaycox LH, Duan N, LaBorde AP, Rea MM, Murray P, Anderson M, Landon C, Tang L, Wells KB. Effectiveness of a quality improvement intervention for adolescent depression in primary care clinics: a randomized controlled trial [see comment]. JAMA 2005;293(3):311-9.

Baldwin R. Does a nurse-led mental health liaison service for older people reduce psychiatric morbidity in acute general medical wards? A randomised controlled trial. Age and Ageing 2004;33(5):472.

Bogner HR, de-Vries HF. Integration of depression and hypertension treatment: a pilot, randomized controlled trial. Annals of family medicine 2008;6(4):295–301.

Ciechanowski P, Wagner E, Schmaling K, Schwartz S, Williams B, Diehr P, Kulzer J, Gray S, Collier C, LoGerfo J. Community-integrated home-based depression treatment in older adults: a randomized controlled trial. JAMA 2004;(13):1569–77.

Chew-Graham CA, Lovell K, Roberts C, Baldwin R, Morley M, Burns A, Richards D, Burroughs H. A randomised controlled trial to test the feasibility of a collaborative care model for the management of depression in older people. British.Journal of General.Practice 2007;57(538):364-70.

Cole MG, McCusker J, Elie M, Dendukuri N, Latimer E, Belzile E. Systematic detection and multidisciplinary care of depression in older medical inpatients: a randomized trial. Canadian Medical Association Journal 2006;174(1):38-44.

Cullum S, Tucker S, Todd C, Brayne C, Effectiveness of liaison psychiatric nursing in older medical inpatients with depression: a randomised controlled trial. Age and Ageing 2007;36(4):436-42.

Dietrich AJ, Oxman TE, Williams JWJ, Schulberg HC, Bruce ML, Lee PW, Barry S, Raue PJ, Lefever JJ, Heo M, Rost K, Kroenke K, Gerrity M, Nutting PA. Re-engineering systems for the treatment of depression in primary care: cluster randomised controlled trial. British Medical Journal 2004;329(7466):602.

Dobscha SK, Corson K, Hickam DH, Perrin NA, Kraemer DF, Gerrity MS. Depression decision support in primary care: a cluster randomized trial [see comment] [summary for patients in Ann Intern Med 2006;145(7):I10; PMID: 17015861]. Annals of Internal Medicine 2006;145(7):477-87.

Dwight-Johnson M, Ell K, Lee PJ. Can collaborative care address the needs of low-income Latinas with comorbid depression and cancer? Results from a randomized pilot study. Psychosomatics 2005;46(3):224-32.

Ell K, Unutzer J, Aranda M, Gibbs NE, Lee PJ, Xie B. Managing depression in home health care: a randomized clinical trial. Home Health Care Services Quarterly 2007;26(3):81-104..

Ell K, Xie B, Quon B, Quinn DI, Dwight-Johnson M, Lee PJ. Randomized controlled trial of collaborative care management of depression among low-income patients with cancer. Journal of Clinical Oncology 2008;26(27):448-96.


Fortney JC, Pyne JM, Edlund MJ, Williams DK, Robinson DE, Mittal D, Henderson KL. A randomized trial of telemedicine-based collaborative care for depression. Journal of General Internal Medicine 2007;22(8):1086-93.

Gallo JJ, Bogner HR, Morales KH, Post EP, Lin JY, Bruce ML. The effect of a primary care practice-based depression intervention on mortality in older adults: a randomized trial. Annals of Internal Medicine 2007;146(10):689–98.

Gensichen J, von Korff M, Peitz M, Muth C, Beyer M, Güthlin C, Torge M, Petersen JJ, Rosemann T, König J, Gerlach FM. Case management for depression by health care assistants in small primary care practices: a cluster randomized trial. Annals of Internal Medicine 2009;151:369-378.

Joubert J, Joubert L, Reid C, Barton D, Cumming T, Mitchell P, House M, Heng R, Meadows G, Walterfang M, Pantelis C, Ames D, Davis S. The positive effect of integrated care on depressive symptoms in stroke survivors. Cerebrovascular Diseases 2008;26(2):199-205.

Ludman EJ, Simon GE, Grothaus LC, Luce C, Markley DK, Schaefer J. A pilot study of telephone care management and structured disease self-management groups for chronic depression. Psychiatric Services 2007;58(8):1065-72.

McMahon L, Foran KM, Forrest SD, Taylor ML, Ingram G, Rajwal M, Cornwall PL, Lister-Williams RH. Graduate mental health worker case management of depression in UK primary care: a pilot study. British Journal of General Practice 2007;57(544):880-5.

Oslin DW, Thompson R, Kallan MJ, TenHave T, Blow FC, Bastani R, Gould RL, Maxwell AE, Rosansky J, Van SW, Jarvik L. Treatment effects from UPBEAT: a randomized trial of care management for behavioral health problems in hospitalized elderly patients. Journal of Geriatric Psychiatry and Neurology 2004;17(2):99-106.

Reiss-Brennan B, xBriot G, Daumit G, Ford D. Evaluation of "Depression in Primary Care" Innovations. [References]. Adm Policy Ment Health 2006;33(1):91.

Richards DA, Lovell K, Gilbody S, Gask L, Torgerson D, Barkham M, Bland M, Bower P, Lankshear AJ, Simpson A, Fletcher J, Escott D, Hennessy S, Richardson R. Collaborative care for depression in UK primary care: a randomized controlled trial. Psychological Medicine 2008;38(2):279-87.

Rollman BL, Belnap BH, LeMenager MS, et al. Telephone-delivered collaborative care for treating post-CABG depression: a randomized controlled trial. JAMA 2009;302(19):2095-103.


Schrader G, Cheok F, Hordacre AL, Marker J, Wade V, Effect of psychiatry liaison with general practitioners on depression severity in recently hospitalised cardiac patients: a randomised controlled trial. Medical.Journal of Australia 2005;182(6):272-6.

Sharpe M, Strong V, Allen K, Rush R, Maguire P, House A, Ramirez A, Cull A., Management of major depression in outpatients attending a cancer centre: a preliminary evaluation of a multicomponent cancer nurse-delivered intervention. British Journal of Cancer 2004;90(2):310-3.

Simon GE, Ludman EJ, Operskalski BH. Randomized trial of a telephone care management program for outpatients starting antidepressant treatment. Psychiatric Services 2006;57(10):1441-5.

Simon GE, Katon WJ, Lin EH, Rutter C, Manning WG, von Korff M, Ciechanowski P, Ludman EJ, Young BA. Cost-effectiveness of systematic depression treatment among people with diabetes mellitus[see comment]. Archives of General Psychiatry 2007;64(1):65-72.

Smit A, Kluiter H, Conradi HJ, van der Meer K, Tiemens BG, Jenner JA, van Os TW, Ormel J. Short-term effects of enhanced treatment for depression in primary care: results from a randomized controlled trial. Psychological Medicine 2006;36(1):15-26.

Stiefel F, Zdrojewski C, Bel Hadj F, Boffa D, Dorogi Y, So A, Ruiz J, de Jonge P. Effects of a multifaceted psychiatric intervention targeted for the complex medically ill: a randomized controlled trial. Psychotherapy and Psychosomatics 2008;77(4):247-56.

Strong V, Waters R, Hibberd C, Murray G, Wall L, Walker J, McHugh G, Walker A, Sharpe M. Management of depression for people with cancer (SMaRT oncology 1): a randomised trial. Lancet 2008;372(9632):40-8.

Wang PS, Simon GE, Avorn J, Azocar F, Ludman EJ, McCulloch J, Petukhova MZ, Kessler RC. Telephone screening, outreach, and care management for depressed workers and impact on clinical and work productivity outcomes: a randomized controlled trial [see comment]. JAMA 2007;298(12):1401-11.

Wells KB, Tang L, Miranda J, Benjamin B, Duan N, Sherbourne CD. The effects of quality improvement for depression in primary care at nine years: results from a randomized, controlled group-level trial. Health Services Research 2008;43(6):1952-74.

Williams LS, Kroenke K, Bakas T, Plue LD, Brizendine E, Tu W, Hendrie H. Care management of poststroke depression: a randomized, controlled trial. Stroke 2007;38(3):998-1003.

Additional References Related to the Included Studies

Bogner HR, Morales KH, Post EP, Bruce ML. Diabetes, depression, and death: a randomized controlled trial of a depression treatment program for older adults based in primary care (PROSPECT). Diabetes Care 2007;30(12):3005–10.

Cheok F, Schrader G, Banham D, Marker J, Hordacre AL. Identification, course, and treatment of depression after admission for a cardiac condition: rationale and patient characteristics for the Identifying Depression As a Comorbid Condition (IDACC) project. The American Heart Journal 2003;146(6):978-84.

Reiss-Brennan B, Briot P, Cannon W, James B. Mental health integration: rethinking practitioner roles in the treatment of depression: the specialist, primary care physicians, and the practice nurse. Ethnicity & Disease 2006;16(2 Suppl 3):37-43.

Reiss-Brennan B, Cannon W, Smith D, Flint T, Wilcox A, Briot Pl, Snow G, James B, Cattrell V. IHC Mental Health Integration - Primary Care Clinical Programs, IHC Community Team, 2003. Depression – Key Levers to Overcome Barriers to High Quality Care. Iowa Coalition on Mental Health & Aging. University of Iowa. [www.public-health.uiowa.edu/icmha/outreach/documents/Depression--KeyLeverstoOvercomeBarrierstoHighQualityCare_000.pdf - Accessed 07/29/2011]

Reiss-Brennan B. Can mental health integration in a primary care setting improve quality and lower costs? A case study. Journal of Managed Care Pharmacy 2006;12(2 Suppl):14 – 20.

Reiss-Brennan B, Briot PC, Savitz LA, Cannon W, Staheli R. Cost and quality impact of intermountain's mental health integration program. Journal of Healthcare Management 2010;55(2):97-113 [discussion 113-4].

Rubenstein LV, Jackson-Triche M, Unutzer J, Miranda J, Minnium K, Pearson ML, Wells KB. Evidence-based care for depression in managed primary care practices. Health Affairs 1999;18(5):89-105.

Sharpe M, Strong V, Allen K, Rush R, Postma K, Tulloh A, Maguire P, House A, Ramirez A, Cull A. Major depression in outpatients attending a regional cancer centre: screening and unmet treatment needs. British Journal of Cancer 2003;90(2):314-20.

Sherbourne CD, Edelen MO, Zhou A, Bird C, Duan N, Wells KB. How a therapy-based quality improvement intervention for depression affected life events and psychological well-being over time: a 9-year longitudinal analysis. Medical Care 2008;46(1):78-84.

Unknown. Care managers affect worker productivity. Disease Management Advisor 2007;13(12):133-7.

Wells KB. The design of Partners in Care: evaluating the cost-effectiveness of improving care for depression in primary care. Social Psychiatry & Psychiatric Epidemiology 1999;34(1):20-9.